In a skillet over medium heat, cook the chopped bacon until crispy. Remove the bacon from the skillet and let it drain on a paper towel, reserving some of the bacon fat in the pan.

In a large mixing bowl, combine the ground venison, cooked bacon, mashed blackberries, breadcrumbs, Worcestershire sauce, salt, black pepper, garlic powder, and onion powder. Mix gently until just combined, being careful not to overwork the meat.

Divide the mixture into four equal portions and shape them into patties. Make a small indentation in the center of each patty to help them cook evenly.

Heat the skillet with the reserved bacon fat over medium-high heat. Once hot, add the patties to the skillet and cook for about 4-5 minutes on each side, or until they reach your desired level of doneness.

While the burgers are cooking, toast the hamburger buns in a separate skillet or on a grill until golden brown.

Assemble the burgers by placing a patty on each bun, and topping with lettuce, sliced tomatoes, sliced red onion, and any additional condiments you prefer.

Serve immediately and enjoy the delightful flavors of blackberry, bacon, and venison.