Preheat your oven to 350°F (175°C).
In a bowl, combine olive oil, smoked paprika, cayenne pepper, garlic powder, and Worcestershire sauce.
Coat the roast beef slices with the spice mixture, ensuring even coverage.
Arrange the seasoned roast beef on a baking sheet and warm in the oven.
While the beef is warming, slice the slider buns in half and place them on another baking sheet.
Prepare the spicy mayonnaise while the beef and buns warm.
Once the beef is heated through and buns are toasted, assemble the sliders: bottom bun, beef, spicy mayo, lettuce, and pickles.
Place the tops of the buns on each slider and serve immediately.